Dr. Jefferson received his MD from the University of Wisconsin. Following a medical internship at St. Luke's Hospital in New York, he completed a residency in Internal Medicine at the University of Wisconsin and a Cardiology Fellowship at the University of Chicago. After serving with the military as a research cardiologist, he completed a residency in Psychiatry at the University of Wisconsin. He joined the faculty in 1974, was tenured in 1978, served as Professor of Psychiatry from 1981 -1992 and as Director of the Center for Affective Disorders from 1983 - 1992. He is board certified in both Psychiatry and Internal Medicine.

Between 1992 and 1998, Dr. Jefferson served as a Distinguished Senior Scientist at the Dean Foundation for Health, Research and Education. In 1998 Dr. Jefferson became a Distinguished Senior Scientist at the Madison Institute of Medicine. He is also Clinical Professor of Psychiatry at the University of Wisconsin Medical School. In addition, he is Co-Founder of the Lithium Information Center, Bipolar Disorders Treatment Information Center and Obsessive Compulsive Information Center and President of Healthcare Technology Systems. His major clinical and research interests are in mood and anxiety disorders, psychopharmacology and the medical/psychiatry interface. In addition to numerous articles in professional journals and chapters in books, he has co-authored books such as Handbook of Medical Psychiatry, Depression and Its Treatment, Anxiety and Its Treatment, Primer of Lithium Therapy, Lithium Encyclopedia for Clinical Practice, and Neuropsychiatric Features of Medical Disorders and patient booklets in the Madison Institute of Medicine's guide series, including Lithium and Manic Depression, Divalproex and Manic Depression, Panic Disorder and Agoraphobia, Social Anxiety Disorder, Depression and Antidepressants, Antipsychotic Medications, Posttraumatic Stress Disorder, Premenstrual Dysphoric Disorder and Oxcarbazepine and Bipolar Disorder. Dr. Jefferson has lectured extensively throughout the world on these and related topics.

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