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Tricyclic Antidepressants (TCAs) The tricyclic antidepressants share a common three-ring or "tricyclic" chemical structure, but they are not identical. The composition of the rings and the chemicals attached to the rings are what make them different. Since their general chemical properties are similar, their mode of action and their side effects are somewhat alike. For more detailed information about tricyclic antidepressants, including side effects, cautions and interactions with food and other medications, click here to download the Madison Institute of Medicine's® Guide on PTSD.
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